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1月12日 杨磊:Mechano-active biomaterials for tissue repair and regeneration


报告题目:Mechano-active biomaterials for tissue repair and regeneration

报告人:杨磊 河北工业大学

主持人:罗剑 教授

报告时间:2021年1月12日上午10:10(周二上午)

报告地点:生命科学学院534小会议室


报告人简介:

杨磊,清华大学材料学学士、硕士,美国布朗大学工学博士、创新与创业管理硕士。历任苏州大学骨科研究所副所长、教授。现任河北工业大学健康科学与工程研究中心主任、教授。入选国家级海外人才项目及国家自然科学基金杰青、优青项目。近五年来在Nature Biomed Eng、Mater Today、Spine J、ACS Nano、Adv Funct Mater、Adv Sci 等期刊上发表论文40余篇;由Elsevier出版英文专著2部 ;申请中国发明30余项(授权13项)、美国授权发明2项。曾获国际矫形与创伤外科学会SICOT基础研究奖(全球每年1人)、中国创新创业大赛生物医药行业全国第二名、美国生物材料学会SFB博士生奖、美国Sigma Xi学会“全美125位青年学者奖”等。现任期刊Int J Nanomed(IF=5.115)副主编、中国材料研究学会青委会理事、中华医学会骨科学分会创新与转化学组委员、中国老年学和老年医学学会骨科分会基础学组副组长、国际矫形与创伤外科学会SICOT中国部骨科基础学会常委、中国生物材料学会生物陶瓷分会委员、中国机械工程学会生物制造工程分会委员等学会任职。


报告内容:

There is a lack of effective tissue repair and regeneration strategies in current clinical practices. Numerous studies have suggested that smart or responsive biomaterials possessing the ability to respond to endogenous stimuli in vivo may positively mediate the tissue micro-environment towards a tissue repair or regeneration. Mechanical stimuli, which constantly exist in a wide range of biological systems and are involved in almost all the physiological processes, belong to such stimuli to which responsive biomaterials can respond. Based on recent studies, a new type of smart biomaterials has emerged that can dynamically adapt to the mechanical stimuli in vivo and thus has specific functionality consistently mediated by such mechanical stimuli. In contrast to common biomaterials that only passively react to the mechanical environment of an implantation site, such mechano-active biomaterials have enabled various active or automatic strategies for tissue repair or regeneration, such as providing precise spatial-temporal controls on delivery of drugs or cells in the organs of the musculoskeletal and the circulatory systems; in situ reconstructing the original or a favorable mechanical environment at a lesion site; and accelerating the tissue remodeling or healing process via a mechanobiological effect. This talk elucidates a perspective of perfecting tissue repair or regeneration using mechano-active biomaterials, especially highlighting the rationale behind the concept of mechano-active biomaterials and their potential in the repair or regeneration of musculoskeletal and cardiovascular tissues.


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